1. Epigenetics
  2. Histone Demethylase
  3. T-448 free base

T-448 free base 

目录号: HY-122635
产品使用指南

T-448 free base 是赖氨酸特异性去甲基化酶1 (LSD1,一种H3K4去甲基化酶) 不可逆的、口服有效的抑制剂,IC50 值为 22 nM。T-448 free base能够加强原代培养的大鼠神经元中H3K4的甲基化。

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T-448 free base Chemical Structure

T-448 free base Chemical Structure

CAS No. : 1597426-52-2

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Description

T-448 free base is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons[1].

IC50 & Target

IC50: 22 nM (LSD1)[1].

In Vitro

T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction[1].

Cell Viability Assay

Cell Line: Primary cultured rat neurons.
Concentration: 0-10 μM.
Incubation Time: 1 day treatment.
Result: Increased Ucp2 H3K4me2 and Ucp2 mRNA significantly.
In Vivo

T-448 has minimal impact on the LSD1-GFI1B complex and a superior hematological safety profile in mice via the generation of a compact formyl-FAD adduct. T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction[1].
T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg[1].

Animal Model: NR1-hypo mice[1].
Dosage: 1, 10 mg/kg.
Administration: Orally, 3 weeks.
Result: Dose-dependently increased the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus.
Resulted in partial but statistically significant and dosedependent rescue effects on the rate of correct choices in NR1-hypo mice.
Molecular Weight

328.43

Formula

C₁₇H₂₀N₄OS

CAS No.

1597426-52-2

SMILES

O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

T-448T448T 448Histone DemethylaseInhibitorinhibitorinhibit

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T-448 free base
目录号:
HY-122635
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