2. Anti-infection
  3. Antibiotic Bacterial
  4. Temafloxacin hydrochloride

Temafloxacin hydrochloride  (Synonyms: TMFX hydrochloride; TA-167; A-62254)

目录号: HY-113595
产品使用指南

摩尔计算器

Temafloxacin (TMFX) hydrochloride 是一种口服有效的喹诺酮类广谱抗菌剂。Temafloxacin hydrochloride 对下呼吸道和泌尿生殖道感染具有较好的耐受性。

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Temafloxacin hydrochloride Chemical Structure

Temafloxacin hydrochloride Chemical Structure

CAS No. : 105784-61-0

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Temafloxacin hydrochloride 的其他形式现货产品:

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Other Forms of Temafloxacin hydrochloride:

Temafloxacin hydrochloride 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2].

IC50 & Target

Quinolone

 

体外研究
(In Vitro)

Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Temafloxacin hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains)
Concentration: 0-64 µg/mL
Incubation Time: 18-24 h
Result: Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).
体内研究
(In Vivo)

Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1].
Dosage: 6.25, 25, 100 mg/kg
Administration: Orally; single.
Result: Reduced the number of viable bacteria in the kidneys of mice.
Animal Model: Female CF-1 mice (20-25 g)[1].
Dosage: 100 mg/kg
Administration: Subcutaneously or orally; single.
Result: 1.19 Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery
SC (100 mg/kg) 25.2 86.6 3.4 25.3
PO (100 mg/kg) 13.5 57.4 1.3 9.1
分子量

453.84

Formula

C21H19ClF3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Temafloxacin hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Temafloxacin105784-61-0TMFX TA-167 A-62254TA167TA 167TA-167A62254A 62254A-62254AntibioticBacterialE. coliP. aeruginosaS. aureusmurine pyelonephritisgram-positivegram-negativeanaerobicInhibitorinhibitorinhibit

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