2. Others Membrane Transporter/Ion Channel
  3. CFTR Isotope-Labeled Compounds
  4. Tezacaftor-d6

Tezacaftor-d6  (Synonyms: VX-661-d6)

目录号: HY-15448S1
产品使用指南 技术支持

Tezacaftor-d6 (VX-661-d6) 是氘代标记的 Tezacaftor. Tezacaftor (VX-661) 是一种 F508del CFTR 校正子。它有助于 CFTR 蛋白到达细胞表面。 然而，Ivacaftor (VX-770，HY-13017) 这种 CFTR 增效剂，有助于延长细胞表面 CFTR 蛋白通道的开放时间。Tezacaftor 与 Ivacaftor 结合，显示出对囊性纤维化和 CFTR Phe508del 突变纯合子疾病的有力效果。此外，Elexacaftor (VX-445，HY-111772) 也是一种 CFTR 校正器。 Elexacaftor-Tezacaftor-Ivacaftor 针对至少有一个 Phe508del 突变的囊性纤维化（CF），通常可避免肺移植适应症。

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Tezacaftor-d<sub>6</sub>

Tezacaftor-d6 Chemical Structure

CAS No. : 1961280-94-3

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Other Forms of Tezacaftor-d6:

Tezacaftor-d6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tezacaftor-d6 (VX-661-d6) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation[1][2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tezacaftor-d6 相关抗体:
分子量

526.53

Formula

C26H21D6F3N2O6
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tezacaftor-d6 相关分类

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  • 稀释计算器

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Keywords:

Tezacaftor-d61961280-94-3VX-661-d6CFTRIsotope-Labeled CompoundsCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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