2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation GPCR/G Protein
  3. Mitochondrial Metabolism TNF Receptor IFNAR CXCR
  4. TFAM activator 1

TFAM activator 1 (Compound 2) 是一种线粒体转录因子 A (TFAM) 激活剂。TFAM activator 1 具有抗炎和修复线粒体功能障碍活性。TFAM activator 1 可增加 TFAM 蛋白水平和线粒体 DNA 拷贝数，并通过阻止线粒体 DNA 逃逸到胞质溶胶来抑制线粒体 DNA 应激介导的炎症反应，从而减少细胞因子 (TNF-α、CXCL-10 和 IFN) 的产生。TFAM activator 1 可显著提高 ATP 水平，降低纤维化标志物，并增强 Treg 240 的功能。TFAM activator 1 可用于线粒体功能障碍，例如帕金森病和阿尔茨海默病的研究。

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TFAM activator 1

TFAM activator 1 Chemical Structure

CAS No. : 932992-44-4

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TFAM activator 1 相关抗体

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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  • 生物活性

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  • 参考文献

生物活性

TFAM activator 1 (Compound 2) is a Transcription Factor A, Mitochondrial (TFAM) activator. TFAM activator 1 has an anti-inflammatory and mitochondrial dysfunction restoration activity. TFAM activator 1 increases TFAM protein levels and mtDNA copy number and inhibits mtDNA stress-mediated inflammatory responses with reduced cytokine (TNF-α, CXCL-10 and IFN) production by preventing mtDNA escape into the cytosol. TFAM activator 1 significantly increases ATP level, reduces fibrotic markers and enhances Treg 240 function. TFAM activator 1 can be used for mitochondrial dysfunction, such as Parkinson’s and Alzheimer’s diseases research[1].

分子量

373.43

Formula

C18H19N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TFAM activator 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TFAM activator 1932992-44-4TFAM activator1TFAM activator-1Mitochondrial MetabolismTNF ReceptorIFNARCXCRTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptor CXC chemokine receptorsC-X-C motif chemokine receptorsTranscription Factor AMitochondrialTFAMA549 cells22RV1 cellsA172 cellsT47D cellsAnti-inflammatoryMitochondrial dysfunctionParkinson’s diseaseAlzheimer’s diseaseInhibitorinhibitorinhibit

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