1. Signaling Pathways
  2. Immunology/Inflammation
  3. IFNAR

IFNAR

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric cell surface receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. Upon binding of type I IFNs, IFNAR activates the JAK-STAT signaling pathway. Interferon stimulation classically results in an anti-viral immune response. Type I IFNs share a common receptor consisting of two subunits, IFNAR1 and IFNAR2, which associate upon IFN binding. IFNAR2 is the major ligand binding component of the receptor complex, exhibiting nanomolar affinity to both IFNα and IFNβ subtypes. IFNAR1 and IFNAR2 belong to the class II helical cytokine receptor (hCR) family, which includes the receptor for type II IFN, tissue factor (TF), and IL10Rβ.

IFNAR 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP是氧化磷酸化解偶联剂。
  • HY-12836A
    IFN alpha-IFNAR-IN-1 hydrochloride Inhibitor 99.76%
    IFN alpha-IFNAR-IN-1盐酸盐是IFN alpha和其受体IFNAR相互作用抑制剂,EC50值2-8 μM。
  • HY-107390A
    AX-024 hydrochloride Inhibitor 99.29%
    AX-024 hydrochloride 是一种口服可利用的,一流的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化,IC50 值为 1 nM。AX-024 hydrochloride 通过靶向 SH3 结构域调节细胞信号传导。AX-024 hydrochloride 具有低毒、高效、高选择性的特点。AX-024 hydrochloride 有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。
  • HY-107390
    AX-024 Inhibitor >98.0%
    AX-024 是一种口服可利用的,一流的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化,IC50 值为 1 nM。AX-024 通过靶向 SH3 结构域调节细胞信号传导。AX-024 具有低毒、高效、高选择性的特点。AX-024 有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。
  • HY-112189
    Interferon receptor inducer-1 Agonist 98.49%
    Interferon receptor inducer-1 (compound 6) 是干扰素 (IFN) 受体的一个诱导剂。可用于治疗干扰素诱导参与的紊乱性疾病。
  • HY-W011890
    Cridanimod Activator 99.82%
    Cridanimod 是一种小分子免疫调节剂和干扰素诱导剂。Cridanimod 是一种有效的孕酮受体 (PR) 激活剂,通过诱导 IFNαIFNβ 的表达可显着增加 PR 的表达。
  • HY-P1758
    IFN-α Receptor Recognition Peptide 1
    IFN-α Receptor Recognition Peptide 1 是 IFN-α 的一个多肽序列,为 IFN-α 受体识别肽。
  • HY-12836
    IFN alpha-IFNAR-IN-1 Inhibitor
    IFN alpha-IFNAR-IN-1是IFN alpha和其受体IFNAR相互作用抑制剂,EC50值2-8uM。
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