2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. TGF-β2-IN-1

TGF-β2-IN-1 是一种选择性 TGF-β2 抑制剂。TGF-β2-IN-1 对 HCT-116、Caco-2 和 HT-29 细胞表现出强大的抗增殖作用，IC50 值分别为 6.84、10.21 和 9.47 μM。TGF-β2-IN-1 以剂量依赖性方式抑制 TGF-β2 信号传导，通过抑制受体和细胞因子表达实现。TGF-β2-IN-1 可用于结直肠癌的研究。

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TGF-β2-IN-1

TGF-β2-IN-1 Chemical Structure

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Customer Review

TGF-β2-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGF-β2-IN-1 is a selective TGF-β2 inhibitor. TGF-β2-IN-1 exhibits potent antiproliferative effects on HCT-116, Caco-2 and HT-29 with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing both receptor and cytokine expression.TGF-β2-IN-1 can be used for the study of colorectal cancer[1].

体外研究
(In Vitro)

TGF-β2-IN-1 (Compound 10k) (1.562-100 μM, 48 h) 对 HCT-116 (IC50 = 6.84 μM)、Caco-2 (IC50 = 10.21 μM) 和 HT-29 (IC50 = 9.47 μM) 表现出强大的抗增殖作用[1]。
TGF-β2-IN-1 (1.562-100 μM, 48 h) 在 HCT-116 细胞中逐渐降低 TGF-β2 受体水平和 TGF-β2 细胞因子水平[1]。
TGF-β2-IN-1 (50-100 μM, 48 h) 在 HCT-116 细胞中未显著诱导细胞凋亡或坏死[1]。
TGF-β2-IN-1 对 TGF-β 受体 II 型显示出强烈的结合亲和力，IFD XP Glide 评分为 11.28 kcal/mol[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TGF-β2-IN-1 相关抗体:

ELISA Assay[1]

Cell Line: HCT-116 cells
Concentration: 1.562, 3.125, 6.25, 12.5, 25, 50, 100 μM
Incubation Time: 48 h
Result: Led to progressive reductions in TGF-β2 receptor levels and TGF-β2 cytokine levels in HCT-116 cells.
Showed more pronounced inhibition of the receptor component of the pathway than Sorafenib (HY-10201).
分子量

475.93

Formula

C25H22ClN5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGF-β2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGF-β2-IN-1TGF-beta/SmadTransforming growth factor betaHCT-116 cellsCaco-2 cellsHT-29 cellscolorectal cancerTGF-β2Inhibitorinhibitorinhibit

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目录号：
HY-175205
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