2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. Trimethylamine oxide-15N

Trimethylamine oxide-15N 是 Trimethylamine N-oxide (HY-116084) 的氘代物。Trimethylamine N-oxide 是一种膳食胆碱和其他含三甲胺营养素的肠道微生物依赖性代谢产物。Trimethylamine N-oxide 通过激活 ROS/NLRP3 炎性体诱导炎症。Trimethylamine N-oxide 还通过激活 TGF-β/smad2 信号通路来加速成纤维细胞的分化并诱导心脏纤维化。

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Trimethylamine oxide-<sup>15</sup>N Chemical Structure

Trimethylamine oxide-15N Chemical Structure

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Trimethylamine oxide-15N 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trimethylamine oxide-15N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethylamine oxide-15N 相关抗体:
分子量

76.10

Formula

C3H915NO
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trimethylamine oxide-15N 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Trimethylamine oxide-15NReactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

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