2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC3/6-IN-1

TRPC3/6-IN-1 是有效的选择性瞬时受体通道 (TRPC3/6) 分子阻滞剂，可阻滞 hTRPC3 和 hTRPC6，IC50 值分别为 1260 nM 和 500 nM。TRPC3/6-IN-1 可用于慢性心力衰竭模型的研究。

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TRPC3/6-IN-1 Chemical Structure

TRPC3/6-IN-1 Chemical Structure

CAS No. : 736945-96-3

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TRPC3/6-IN-1 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].

IC50 & Target

hTRPC3

1260 nM (IC50)

hTRPC6

500 nM (IC50)

体外研究
(In Vitro)

TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRPC3/6-IN-1 相关抗体:
体内研究
(In Vivo)

TRPC3/6-IN-1 (compound 3) has good pharmacokinetic in rats[1].
Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1].

Compd Dose(iv)(mg/kg) Cmax(iv)(ng/ml) CL(iv)(ml/min/kg) MRT(iv)(h) DNAUC(iv)(h•kg/L) %F
3 0.93 250 120 0.3 0.14 ~1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.45

Formula

C20H19N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPC3/6-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC3/6-IN-1736945-96-3TRP ChannelTransient receptor potential channelsreceptor channelsTRPC3TRPC6anilino-thiazoleheart failureInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147357
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