2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPV4 antagonist 4

TRPV4 antagonist 4 是一种有效的 TRPV4 拮抗剂，IC50 值为 22.65 nM。TRPV4 antagonist 4 抑制 TRPV4 电流。TRPV4 antagonist 4 显示出对急性肺损伤的保护作用。

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TRPV4 antagonist 4 Chemical Structure

TRPV4 antagonist 4 Chemical Structure

CAS No. : 2918803-89-9

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TRPV4 antagonist 4 相关抗体

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  • 生物活性

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生物活性

TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1].

IC50 & Target[1]

TRPV4

22.65 nM (IC50)

体外研究
(In Vitro)

TRPV4 antagonist 4 (compound 2b; 1 µM) 抑制 TRPV4-CHO 细胞中 GSK1016790A (HY-19608) (100 nM) 诱导的 TRPV4 全细胞电流[1]。
TRPV4 antagonist 4 抑制 HUVEC 中对 LPS (HY-D1056) 诱导的通透性反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRPV4 antagonist 4 相关抗体:
体内研究
(In Vivo)

TRPV4 antagonist 4 (1 mg/kg; i.p.) 在 LPS 诱导的小鼠肺损伤模式中改善肺水肿和相关肺病理变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (acute lung injury (ALI))[1]
Dosage: 1 mg/kg
Administration: I,p.; before LPS inhalation
Result: Displayed significant effects to reduce the lung W/D ratio and significantly decreased the concentrations of BALF protein, significantly blocked the permeability response to LPS stimulates, greatly improved the pneumonedema, the lung pathologic changes in LPS-induced mouse lung injury mode.
分子量

539.50

Formula

C28H32Cl2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPV4 antagonist 4 相关分类

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Keywords:

TRPV4 antagonist 42918803-89-9TRP ChannelTransient receptor potential channelsTRPV4 currentacute lung injurypermeability responseInhibitorinhibitorinhibit

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