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  3. Parasite
  4. Trypanothione synthetase-IN-1

Trypanothione synthetase-IN-1 

目录号: HY-151148
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摩尔计算器

Trypanothione synthetase-IN-1 (Compound 1) 是一种竞争性的婴儿利什曼虫锥虫胱甘肽合成酶 (TryS) 抑制剂，当三胺亚精胺作为多胺 S 时，IC50 为 14.8 μM。

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Trypanothione synthetase-IN-1 Chemical Structure

Trypanothione synthetase-IN-1 Chemical Structure

CAS No. : 2355349-41-4

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Trypanothione synthetase-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].

IC50 & Target

Leishmania

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
≥ 75 μM
Compound: 19c
Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay
[PMID: 33945281]
THP-1 EC50
> 75 μM
Compound: 19c
Cytotoxicity against human THP-1 cells by LDH assay
Cytotoxicity against human THP-1 cells by LDH assay
[PMID: 33945281]
体外研究
(In Vitro)

Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1].
Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: L. infantum, HepG2
Concentration: 0-75 μM
Incubation Time: 24 h (L. infantum axenic amastigotes) or 72 h
Result: Showed leishmanicidal activity with EC50s of 21.5 ± 2.4 μM and 13.5 ± 0.9 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of 15.9 ± 0.4 μM against HepG2 cells.
分子量

785.83

Formula

C40H38F3N7O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trypanothione synthetase-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-12355349-41-4ParasiteleishmanicidalLeishmania infantumtrypanothione synthetaseTrySInhibitorinhibitorinhibit

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