2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 17

Tubulin inhibitor 17 (Compound 3b) 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂，IC50 为 12.38 µM。Tubulin inhibitor 17 具有抗癌活性，诱导细胞凋亡 (apoptosis)。

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Tubulin inhibitor 17 Chemical Structure

Tubulin inhibitor 17 Chemical Structure

CAS No. : 2839151-13-0

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Tubulin inhibitor 17 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC50 of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis[1].

IC50 & Target

IC50: 12.38 µM (tubulin polymerization)[1]
体外研究
(In Vitro)

Tubulin inhibitor 17 (Compound 3b) (0-10 µM, 0-72 h) displays antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells[1].
Tubulin inhibitor 17 (0-2.5 µM) inhibits tubulin polymerization in a concentration-dependent manner[1].
Tubulin inhibitor 17 (0-1 µM, 12 h) induces the collapse of the microtubule networks in a dose-dependent manner[1].
Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase and inhibits cell migration in HepG-2 cells[1].
Tubulin inhibitor 17 (0-5 μM, 48 h) induces HepG-2 cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 17 相关抗体:

Cell Proliferation Assay[1]

Cell Line: B16-F10, HepG-2, Hela and MCF-7
Concentration: 0, 0.5, 2.5, 5.0, 7.5 and 10 µM
Incubation Time: 48 h for IC50 measurement, 0-72 h for cell viability
Result: Displayed antiproliferative activities with IC50 values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 µM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a time- and concentration- dependent manner.

Cell Cycle Analysis[1]

Cell Line: HepG-2
Concentration: 0.5, 1.0 and 5.0 μM
Incubation Time: 24 h
Result: Dose-dependently induced cell cycle arrest at G2/M phase.

Apoptosis Analysis[1]

Cell Line: HepG-2
Concentration: 0.5, 1.0 and 5.0 μM
Incubation Time: 48 h
Result: The total proportion of apoptotic cells were increased significantly compared with the control.
分子量

264.32

Formula

C17H16N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 17 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 172839151-13-0Tubulin inhibitor17Tubulin inhibitor-17Microtubule/TubulinApoptosisB16-F10HepG-2HelaMCF-7anticancer agentInhibitorinhibitorinhibit

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