2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin inhibitor 25

Tubulin inhibitor 25 是一种有效的微管蛋白 (tubulin) 抑制剂，IC50 为 0.98 μM。Tubulin inhibitor 25 对 HT29 细胞有显著的抑制作用。Tubulin inhibitor 25 能抑制细胞迁移和微管形成，有助于抗血管生成。

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Tubulin inhibitor 25 Chemical Structure

Tubulin inhibitor 25 Chemical Structure

CAS No. : 2411697-71-5

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Tubulin inhibitor 25 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 25 is a potent tubulin inhibitor with an IC50 value of 0.98 μM. Tubulin inhibitor 25 exhibits remarkable activity against cancer cell line HT29. Tubulin inhibitor 25 displays the potent inhibition on cell migration and tube formation that contributes to the anti-angiogenesis[1].

IC50 & Target

IC50: 0.98 μM (tubulin)[1]
体外研究
(In Vitro)

Tubulin inhibitor 25 (compound 6c) (0-100 μM; 48 hours) exhibits high antiproliferative activity against tested cancer cell lines[1].
Tubulin inhibitor 25 (0-200 μM; 48 hours) exhibits low cytotoxicity in normal cell lines[1].
Tubulin inhibitor 25 (0.05, 0.1 and 0.2 μM; 24 hours) inhibits the colony formation of HT29 cells in a dose-dependent manner[1].
Tubulin inhibitor 25 (2 and 4 μM) can inhibit the tubulin polymerization and compete with colchicine binding site[1].
Tubulin inhibitor 25 (0.25-1 μM; 12-48 hours) arrests the cell cycle at G2/M phase and induces HT29 cells apoptosis in a dose- and time-dependent manner, besides induces HT29 cell depolarized mitochondria in the process of apoptosis[1].
Tubulin inhibitor 25 (0.25-1 μM; 24 hours) increases the expression of P21 and Cyclin B1 and decreases the expression of Cdc2, p-CDC2 and p-Cdc25c; as well as induces the microtubule collapse in HT29 cells in a dose-dependent manner[1].
Tubulin inhibitor 25 (0.01, 0.02 and 0.04 μM; 6 hours) effectively inhibits the HUVEC tube formation in a dose-dependent manner[1].
Tubulin inhibitor 25 (0.1, 0.2 and 0.4 μM; 24 hours) inhibits migration of A549 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 25 相关抗体:

Cell Proliferation Assay

Cell Line: MDA-MB-231, HepG2, HT29, HCT116 and A549[1]
Concentration: 0-100 μM
Incubation Time: 48 hours
Result: Exhibited high antiproliferative activity against HT29, HCT116, MDA-MB-231 and A549 with IC50s of 0.18 ± 0.04 μM, 0.58 ± 0.11 μM, 0.81 ± 0.13 μM and 0.57 ± 0.79 μM, and less activity against HepG2 with an IC50 of 73.20 ± 4.03 μM.

Cell Cytotoxicity Assay

Cell Line: 293T and LO2[1]
Concentration: 0-200 μM
Incubation Time: 48 hours
Result: Exhibited low cytotoxicity in normal cell lines with CC50s of 184.86 ± 9.88 μM and 154.76 ± 9.98 μM in 293T and LO2.

Cell Cycle Analysis

Cell Line: HT29[1]
Concentration: 0.25, 0.5 and 1 μM
Incubation Time: 12, 24, 36 and 48 hours
Result: Arrested the cell cycle at G2/M phase in a dose-dependent manner with the G2/M cell proportion of 23.05%, 23.55% and 80.99% at 0.25 μM, 0.5 μM and 1 μM, respectively, also exhibited time-dependent manner with the G2/M cell proportion of 32.55%, 36.43% and 71.1% for 12, 36 and 48 hours.

Western Blot Analysis

Cell Line: HT29[1]
Concentration: 0.25, 0.5 and 1 μM
Incubation Time: 24 hours
Result: Increased the expression of P21 and Cyclin B1 and decreased the expression of Cdc2, p-CDC2 and p-Cdc25c.
体内研究
(In Vivo)

Tubulin inhibitor 25 (1.5 mg/kg; IV; single) exhibits good metabolic stability[1].
Pharmacokinetic Parameters of Tubulin inhibitor 25 in male Sprague-Dawley rats[1].

IV (1.5 mg/kg)
T1/2 (h) 3.81 ± 2.14
MRT0-∞ (h) 5.12 ± 2.86
AUC0-∞ (ng/mL·h) 2156.12 ± 851.88
VZ (L/kg) 3.348 ± 0.734

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 1.5 mg/kg
Administration: IV; single (Pharmacokinetic Analysis)
Result: Exhibited good metabolic stability.
分子量

462.45

Formula

C26H22O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 25 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin inhibitor 252411697-71-5Tubulin inhibitor25Tubulin inhibitor-25Microtubule/TubulinMicrotubuleTubulin polymerizationAnticancerHT29Cyclin proteinInhibitorinhibitorinhibit

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