2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Tubulin inhibitor 32

Tubulin inhibitor 32 是一种有效的，具有口服活性的微管 (tubulin) 抑制剂。Tubulin inhibitor 32 显示出抗增殖活性并抑制微管聚合。Tubulin inhibitor 32 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G2/M 期。Tubulin inhibitor 32 具有抗肿瘤活性。

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Tubulin inhibitor 32 Chemical Structure

Tubulin inhibitor 32 Chemical Structure

CAS No. : 2923531-39-7

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Tubulin inhibitor 32 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity[1].

体外研究
(In Vitro)

Tubulin inhibitor 32 (compound 6y) (0-2 µM; 24 h) 以剂量依赖性方式抑制 HCT-116 细胞中集落的形成[1]。
Tubulin inhibitor 32 (0-100 µM; 24 h) 抑制微管聚合，IC50 值为 8.4 µM[1]。
Tubulin inhibitor 32 (0-2 µM; 24, 48 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期[1]。
Tubulin inhibitor 32 在人肝微粒体和大鼠肝微粒体中表现出代谢稳定性，T1/2 值分别为 106.2，6.9 min[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 32 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HepG2, SW480, Hela, MDA-MB-231 cells
Concentration: 0-64 µM
Incubation Time: 48 h
Result: Showed anti-proliferative activity with IC50s of 1.54, 37.53, 24.61, 11.41 µM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0, 0.5, 1, 2 µM
Incubation Time: 48 h
Result: Caused cell cycle arrest in G2/M phase in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0, 0.125, 0.5, 2 µM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose dependent manner.
体内研究
(In Vivo)

Tubulin inhibitor 32 (50、100 mg/kg；口服；每日一次，持续 20 天) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks old male nude mice (HCT-116 tumor model)[1]
Dosage: 50, 100 mg/kg
Administration: P.o.; daily for 20 days
Result: Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively
分子量

325.36

Formula

C18H19N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 32 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 322923531-39-7Tubulin inhibitor32Tubulin inhibitor-32ApoptosisMicrotubule/Tubulinanti-proliferativemicrotubule polymerizationapoptosisG2/Manti-tumororally activeInhibitorinhibitorinhibit

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