2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 33

Tubulin inhibitor 33 是一种微管蛋白聚合抑制剂，以剂量依赖性方式抑制微管蛋白聚合，IC50 为 9.05 μM。Tubulin inhibitor 33 具有抗肿瘤和诱导细胞凋亡 (apoptosis) 作用，可用于抗肿瘤研究。

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Tubulin inhibitor 33 Chemical Structure

Tubulin inhibitor 33 Chemical Structure

CAS No. : 2944462-67-1

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Tubulin inhibitor 33 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research[1].

IC50 & Target

IC50: 9.05 μM (tubulin)[1]
体外研究
(In Vitro)

Tubulin inhibitor 33 (Compound 3a) (0-5 nΜ；24-48 小时) 抑制肿瘤细胞 HepG-2 的增殖、迁移和集落形成，诱导 G2/M 细胞周期阻滞和细胞凋亡[1]。
[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 33 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, HeLa, B16-F10, HepG-2 cells
Concentration: 0-5 nM
Incubation Time: 24-48 hours
Result: Exhibited the antiproliferative activity against the growth of cancer cells with an average IC50 value of 4.5 nM.
Suppressed the formation of HepG-2 colonies in a dose-dependent manner, with the colony-forming ability of HepG-2 cells being significantly suppressed.
Exhibited the antimigratory effects against HepG-2 cells.
Induced G2/M arrest and apoptosis in HepG-2 cells.

Immunofluorescence[1]

Cell Line: HepG-2 cells
Concentration: 0-5 nM
Incubation Time: 12 hours
Result: Effectively inhibited tubulin polymerization in vitro and disrupted microtubule dynamics.
体内研究
(In Vivo)

Tubulin inhibitor 33 (Compound 3a) (5 mg/kg；每天腹腔注射，持续 14 天) 显著抑制黑色素瘤肿瘤生长，TGI 为 62.96%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-F10 melanoma model in C57 mice[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Significantly inhibited melanoma tumor growth with a TGI of 62.96%.
分子量

414.46

Formula

C24H22N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 33 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin inhibitor 332944462-67-1Tubulin inhibitor33Tubulin inhibitor-33Microtubule/TubulinApoptosisIndole AnaloguesMelanomaAntitumorTubulin Polymerization InhibitorMCF-7HelaB16-F10Hepg-2Inhibitorinhibitorinhibit

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目录号：
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