2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin inhibitor 36

Tubulin inhibitor 36 (Compound 10) 是一种新型的强效微管蛋白抑制剂，可抑制微管蛋白的聚合并诱导细胞凋亡，其 IC50 值为 1.5±0.1 μM。Tubulin inhibitor 36 (Compound 10) 具有显著的抗有丝分裂作用，对胶质母细胞瘤 (GBM) 细胞具有活性。Tubulin inhibitor 36 (Compound 10) 具有抗肿瘤作用，可用于胶质母细胞瘤 (GMB) 研究。

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Tubulin inhibitor 36 Chemical Structure

Tubulin inhibitor 36 Chemical Structure

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Tubulin inhibitor 36 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 36 (Compound 10) is a novel and potent tubulin inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC50 value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research[1].

体外研究
(In Vitro)

Tubulin inhibitor 36 (Compound 10) 对人肿瘤细胞系表现出抗增殖活性，针对HeLa, MCF7, U87 MG, T98G, HepG2, HCT8, HT-29细胞的IC50值分别为0.039、0.038、0.022、0.025、0.037、0.040、0.059 μM[1]。
Tubulin inhibitor 36 (Compound 10) (100 nM, 24 h, 48 h, 72 h) 在HeLa, MCF7, and U87 MG细胞中能阻滞有丝分裂并诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 36 相关抗体:

Immunofluorescence[1]

Cell Line: HeLa, MCF7, U87 MG cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Arrested tubulin polymerization in HeLa, MCF7, and U87 MG cells.

Cell Cycle Analysis[1]

Cell Line: HeLa, MCF7, U87 MG cells
Concentration: 100 nM
Incubation Time: 24 h, 48 h, 72 h
Result: Induced remarkable mitotic arrest in 24 h of HeLa cells.
Induced mitotic arrest in 24 h of MCF7 cells but lower cell death compared to HeLa cells
Induced remarkable mitotic arrest in 24 h of U87 MG cells and severe cell death.

Apoptosis Analysis[1]

Cell Line: HeLa, MCF7, U87 MG cells
Concentration: 100 nM
Incubation Time: 72 h
Result: Induced nearly 73% of apoptosis in 72 h of HeLa cells and lower levels of MCF7 cells
Induced lower cell death levels of MCF7 cells
Displayed the highest cell death levels of d U87 MG cells
分子量

356.83

Formula

C16H13ClN6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 36 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 36Tubulin inhibitor36Tubulin inhibitor-36Microtubule/Tubulintubulinglioblastomaantimitotic drugsanticancercolchicine sitetetrazoleindoleInhibitorinhibitorinhibit

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