1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin polymerization-IN-2

Tubulin polymerization-IN-2 是一种靶向 β-微管蛋白的强效抗癌活性分子,IC50 为 0.92 μM。Tubulin polymerization-IN-2 对各种白血病、非小细胞肺癌、肾癌、前列腺癌和乳腺癌细胞系显示出良好的抑制活性。

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Tubulin polymerization-IN-2 Chemical Structure

Tubulin polymerization-IN-2 Chemical Structure

CAS No. : 2873399-22-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines[1].

IC50 & Target

IC50: 0.92 μM (tubulin)[1]

体外研究
(In Vitro)

Tubulin polymerization-IN-2 (compound 2b) shows anti-cancer activity against epidermal carcinoma and breast carcinoma with IC50s of 2.3 μM (KB) and 2.2 μM (BT-549), respectively[1].
Tubulin polymerization-IN-2 (0.342 μM; 24 h) inhibits DNA synthesis or repair, arrests cell cycle at S phase in MCF-7 cells[1].
Tubulin polymerization-IN-2 (0.342 μM; 24 h) induces cell apoptosis by decreasing Bax, APAF-1, and caspase-3 expression and increasing BCL-2 mRNA abundance[1].
Tubulin polymerization-IN-2 (0.01, 0.1, 1, 10 μM; 1 h) has strong interactions on β-tubulin polymerization, with Ki value of 0.09 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

314.29

Formula

C17H12F2N2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tubulin polymerization-IN-2
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HY-143247
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