2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-34

Tubulin polymerization-IN-34 是一种 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂，对边缘区淋巴瘤 VL51 细胞系表现出高选择性。

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Tubulin polymerization-IN-34 Chemical Structure

Tubulin polymerization-IN-34 Chemical Structure

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Tubulin polymerization-IN-34 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-34 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line[1].

IC50 & Target

[1,2]oxazoloisoindoles tubulin polymerization[1]
体外研究
(In Vitro)

Tubulin polymerization-IN-34 (compound 17i) (10 nM-100 μM; 72 h) has antiproliferative activity against 9 NCI subpanels (leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, breast) with GI50s ranging from 0.25 μM to 6.84 μM, and a mean graph_mid point (MG_MID) values of 0.95 μM[1].
Tubulin polymerization-IN-34 (0.15-10 μM; 72 h) shows potent growth inhibitory effects on different lymphoma lines, and demonstrates high selectivity against the VL51 cell line (Marginal zone lymphoma, IC50=0.2 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-34 相关抗体:

Cell Viability Assay[1]

Cell Line: Marginal zone lymphoma, mantle cell lymphoma, activated B-cell like diffuse large B cell lymphoma, germinal center B-cell-like diffuse large B cell lymphoma cells
Concentration: 0.15-10 μM
Incubation Time: 72 h
Result: Inhibited different lymphomas, with IC50s of 0.2 μM (Marginal zone lymphoma); 0.5 μM (mantle cell lymphoma); 0.5 μM (activated B-cell like diffuse large B cell lymphoma); 0.5 μM (germinal center B-cell-like diffuse large B cell lymphoma), respectively.
分子量

545.63

Formula

C31H35N3O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-34Microtubule/TubulinMarginal zone lymphomaMZLmantle cell lymphomaMCLactivated B-cell like diffuse large B cell lymphomaABC-DLBCLgerminal center B-cell-like diffuse large B cell lymphomaGCBDLBCLoxazoloisoindoles tubulin polymerizationInhibitorinhibitorinhibit

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产品名称：
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目录号：
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