2. Anti-infection
  3. HIV
  4. UC-781

UC-781 (NSC 675186) 是一种高效、选择性的人类免疫缺陷病毒 HIV-1 非核苷类逆转录酶抑制剂 (NNRTI)，IC50 值为 5 nM。UC-781 在低 PH 或不同温度下是稳定的。UC-781 具有抗病毒活性和耐药性。

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UC-781 Chemical Structure

UC-781 Chemical Structure

CAS No. : 178870-32-1

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规格 价格 是否有货 数量
1 mg ￥2278
1 周
5 mg   询价  
10 mg   询价  

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UC-781 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].

IC50 & Target[1]

HIV-1

0.005 μM (IC50)

体外研究
(In Vitro)

UC-781 (0.05、0.2 和 0.5 % UC-781 补充凝胶；10 d) 从凝胶制剂中释放出来，并清除 CEM 细胞中的 HIV-1[1]。
UC-781 (3.75 -30 μM) 抑制蜡样芽孢杆菌的生长 (约 50 %)[1]。
UC-781 抑制 CEM T 细胞中的 HIV-1 (ⅢB) 活性 (EC50=6 nM; IC50=23 nM)。UC-781 抑制单核细胞来源的树突状细胞 (MO-DC) 和自体 CD4+ T 细胞中的 HIV 活性，EC50 值分别为 550 nM 和 1588 nM[2]。
UC-781 (1000 nM；24 h) 有效地防止或阻止了单核细胞来源的树突状细胞和自体 CD4+ T 细胞感染 HIV[2]。
UC-781 (0.001-1000 µM；2 h) 抑制病毒转移和宫颈外植体感染 HIV-1BaL[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UC-781 相关抗体:
体内研究
(In Vivo)

UC-781 (100 µl 5% UC-781 补充凝胶；阴道内；一天一次持续 10 天) 从凝胶制剂中释放出来，对雌兔正常组织显示低毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rabbit (~1200 g; 10 weeks old)[1].
Dosage: 100 µl 5% UC-781 replens gel.
Administration: Intravaginal; once daily for 10 days.
Result: Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits.
Clinical Trial
分子量

335.85

Formula

C17H18ClNO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UC-781 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UC-781178870-32-1NSC 675186UC781UC 781NSC675186NSC-675186HIVHuman immunodeficiency virusCEMMO-DCCD4+RabbitInhibitorinhibitorinhibit

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目录号：
HY-15351
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