Urocortin, rat TFA  (Synonyms: Urocortin (Rattus norvegicus) (TFA); Rat urocortin TFA)

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively^[1][2].

Ki: 13 nM (Human CRF₁), 1.5 nM (Rat CRF_2α), and 0.97 nM (Mouse CRF_2β)^[1]

Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀ of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4821.28

C₂₀8H_339N62F3O66

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Perrin MH, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28.  [Content Brief]

  [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.  [Content Brief]

  [3]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.  [Content Brief]