2. Anti-infection
  3. HBV
  4. VNRX-9945

VNRX-9945 是一种强效、广泛的具有口服活性的 HBV 衣壳组装调节剂 (CAM)，其 EC50 值为 2.6 nM。VNRX-9945 在体外对多种基因型 HBV 表现出优异且广泛的抗病毒活性，同时在多个物种中具有良好的药代动力学特征。VNRX-9945 在 AAV-HBV 感染的小鼠模型中显示出强大的抗病毒功效。

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VNRX-9945

VNRX-9945 Chemical Structure

CAS No. : 2396680-45-6

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VNRX-9945 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VNRX-9945 is a potent, broadly and orally active HBV CAM (capsid assembly modulator) with an EC50 of 2.6 nM. VNRX-9945 exhibits excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. VNRX-9945 demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection[1].

体外研究
(In Vitro)

VNRX-9945 (Compound 12) 表现出强大的 HBV 全基因型 (A-H) 抗病毒活性，EC50 值在 3 至 31 nM之间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VNRX-9945 相关抗体:
体内研究
(In Vivo)

VNRX-9945 (10-100 mg/kg，灌胃，每天两次，持续 8 周) 在腺相关病毒乙肝病毒 (AAV-HBV) 感染的小鼠模型中显示出强大的抗病毒效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AAV-HBV mice models (C57BL/6)[1]
Dosage: 10, 30, and 100 mg/kg
Administration: Oral gavage, twice daily for 8 weeks.
Result: Resulted in a significant, dose-dependent reduction in circulating HBV DNA and HBV pgRNA levels.
Led to a > 3 log10 reduction in HBV DNA and an ∼ 2 log10 reduction in HBV pgRNA from baseline at 100 mg/kg.
Showed no changes in HBsAg and HBeAg levels, body weight and ALT levels.
分子量

429.48

Formula

C23H28FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VNRX-9945 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VNRX-99452396680-45-6VNRX9945VNRX 9945HBVHepatitis B virusCAMAAV-HBVInhibitorinhibitorinhibit

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目录号：
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