2. Inhibitory Antibodies
  3. Vopratelimab

Vopratelimab  (Synonyms: JTX 2011)

目录号: HY-P99382 纯度: 95.00%
COA

摩尔计算器

Vopratelimab (JTX-2011) 是一种人源化免疫球蛋白 G1-kappa 激动剂单克隆抗体，特异性结合到诱导型 T 细胞 CO 刺激因子 (ICOS)。Vopratelimab 保留了物种交叉反应性，对 hICOS 的亲和力为 0.93 nM，对大鼠 ICOS 的亲和力为 3.7 nM，对 mICOS 的亲和力为 0.64 nM。Vopratelimab 具有抗肿瘤免疫反应。

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Vopratelimab Chemical Structure

Vopratelimab Chemical Structure

CAS No. : 2039148-04-2

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Vopratelimab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response[1].

体外研究
(In Vitro)

Vopratelimab (JTX-2011; 0.001-10 μg/mL; 3 d; CD4 T 细胞) 具有激活原代人 T 细胞的活性，驱动 IFNγ、IL-17a、IL-10、IL-9、GM-CSF、TNFα 和 IL-21 分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vopratelimab 相关抗体:
体内研究
(In Vivo)

Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; 每周两次，持续 2 周) 促进 Sa1/N 小鼠同基因肿瘤模型中的肿瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female A/J, Balb/c and C57BL/6 mice with Sa1/N murine syngeneic tumor model[1]
Dosage: 0.25-0.3 mg/kg
Administration: Intraperitoneal injection; twice a week, for 2 weeks
Result: Regressed tumor and protected long-term in the Sa1/N murine syngeneic tumor model.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vopratelimab2039148-04-2JTX 2011JTX2011JTX-2011Othersmonoclonal antibodyT cellsantitumorimmuneCD4 T cellsInhibitorinhibitorinhibit

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