2. Apoptosis
  3. TNF Receptor Apoptosis
  4. XmAb5485

XmAb5485 是一种经过 Fc 段改造的人源化抗 CD40 单克隆抗体，对 Fc-γ 受体具有高亲和力。XmAb5485 可诱导针对肿瘤细胞的强效抗体依赖性细胞介导的细胞毒性 (ADCC) 和抗体依赖性细胞吞噬作用 (ADCP)。XmAb5485 能抑制肿瘤细胞增殖并诱导其凋亡 (apoptosis)。XmAb5485 对淋巴瘤、白血病和多发性骨髓瘤细胞系以及原发性癌细胞均显示出高度细胞毒性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

XmAb5485 Chemical Structure

XmAb5485 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

XmAb5485 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells[1].

IC50 & Target

TNFRSF5/CD40
体外研究
(In Vitro)

XmAb5485 在 Ramos 细胞中显示出强大的抗体依赖性细胞吞噬作用 (ADCP)[1]。

XmAb5485 通过抗体依赖性细胞介导的细胞毒性 (ADCC)，抑制多种原发性患者来源的 CLL，MCL 细胞和浆细胞白血病细胞的增殖并诱导其凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

XmAb5485 相关抗体:
体内研究
(In Vivo)

XmAb5485 (6 mg/kg) 使 80% 可检测到肿瘤的小鼠得到治愈，并且在已建立的大体积 (210-350 mm3) 皮下 Ramos 异种移植瘤小鼠模型中显示出显著的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

958  [NCBI]

Accession
靶点

TNFRSF5/CD40
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XmAb5485 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XmAb5485XmAb 5485XmAb-5485TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRCD40Fc gamma receptorsapoptosisADCPADCCCancerLymphomaLeukemiaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
XmAb5485
目录号：
HY-P991555
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z