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ZLc-002 是一种选择性的 nNOS-Capon 抑制剂。ZLc-002 抑制炎症和化疗诱导的神经性疼痛。ZLc-002 可用于焦虑和炎症研究。

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ZLc-002 Chemical Structure

ZLc-002 Chemical Structure

CAS No. : 1446971-41-0

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ZLc-002 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation[1][2][3].

体外研究
(In Vitro)

ZLc-002 (1 μM; 24 h) inhibits nNOS-CAPON in cultured hippocampal neurons from ICR mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZLc-002 相关抗体:

Cell Viability Assay[3]

Cell Line: ICR mice hppocampal neurons
Concentration: 1 μM
Incubation Time: 24 h
Result: Inhibited the nNOS-CAPON in cultured hippocampal neurons from ICR mice.
体内研究
(In Vivo)

ZLc-002 (30 mg/kg; i.p. from 4-10 days until 46 days after stroke everyday) improves motor function in tMCAO mice[1].
ZLc-002 (40 mg/kg; i.v. once per day for seven days) improves chronic mild stress (CMS)-induced anxiety-related behaviours[2].
ZLc-002 (10 μM 1 μL; hippocampus injection once per day for seven days) improves corticosterone (CORT)-induced anxiety-related behaviours[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: tMCAO mice[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg per day; from 4–10 days until 46 days after stroke
Result: Signally ameliorated sroke-induced impairment of motor function and recovered from stroke in the delayed phase.
Animal Model: Adult male ICR mice with CMS exposure[2]
Dosage: 40 mg/kg
Administration: Intravenous injection; 40 mg/kg once per day; from 21-27 days of CMS exposure for 7 days
Result: Showed a therapeutic effect in CMS-induced anxiety disorder.
Animal Model: Adult male ICR mice with CORT[2]
Dosage: 10 μM 1 μL
Administration: Hippocampus injection; 10 μM 1 μL once per day; from 21-27 days of CORT reatmentfor 7 days
Result: Showed a therapeutic effect in chronic stress-induced anxiety disorders.
分子量

231.25

Formula

C10H17NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZLc-002 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLc-0021446971-41-0ZLc002ZLc 002Othersanxiety disordersmall-molecule blockerneuropathicInhibitorinhibitorinhibit

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