1. Immunology/Inflammation
  2. NO Synthase
  3. (Rac)-ZLc-002

(Rac)-ZLc-002 是 nNOS 与一氧化氮合酶 1 衔接蛋白 (NOS1AP) 相互作用的抑制剂,抑制炎症性痛觉和化疗诱导的神经性疼痛,并与 Paclitaxel (HY-B0015) 协同降低肿瘤细胞活力。

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(Rac)-ZLc-002 Chemical Structure

(Rac)-ZLc-002 Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability[1][2].

IC50 & Target

nNOS/NOS1AP interaction[1]

体外研究
(In Vitro)

(Rac)-ZLc-002 (10 μM) 可降低原代培养皮层神经元 NOS1AP 与 nNOS 免疫共沉淀。(Rac)-ZLc-002 在 AlphaScreen 体外结合实验中未能破坏 nNOS-NOS1AP 蛋白-蛋白相互作用。在无细胞检测中无活性[1]
(Rac)-ZLc-002 (10 μM) 可降低共表达全长 nNOS 的 HEK293T 细胞中全长 NOS1AP 的共免疫沉淀,但不能降低 PSD95-PDZ2 的共免疫沉淀[1]
(Rac)-ZLc-002 (0-50 μM; 72 h) 与 Paclitaxel (HY-B0015) 协同降低肿瘤细胞活力[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 4T1 cells
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Treatment alone had no effect on the viability. Showed synergistic effect with Paclitaxel (HY-B0015).
体内研究
(In Vivo)

(Rac)-ZLc-002 (10 mg/kg; i.p.; once or daily for 8 days) 减轻 Paclitaxel (HY-B0015) 引起的机械性和冷性异位痛,抑制 Paclitaxel 诱导的小鼠模型神经性疼痛[1]
(Rac)-ZLc-002 (4 and 10 mg/kg; i.p.; once) 降低大鼠脊髓背角福尔马林诱发的痛觉行为和福尔马林样免疫反应性[1]
(Rac)-ZLc-002 (40 mg/kg/day; i.v.; 7 days) 减弱 ICR 小鼠慢性轻度应激 (CMS) 诱导的焦虑行为[2]
(Rac)-ZLc-002 (10 μM; 1 μl; 30 min after Corticosterone, HY-B1618) 海马体注射 7 天逆转糖皮质激素对小鼠的行为影响[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult C57BL/6J male mice, paclitaxel model of neuropathic pain[1]
Dosage: 10 mg/kg
Administration: IP, once or daily for 8 days
Result: Increased postinjection mechanical paw withdrawal thresholds, mechanical paw withdrawal thresholds differed across postinjection times, and the interaction between drug treatment and injection time was significant. Elevated mechanical paw withdrawal thresholds relative to vehicle treatment from 30 min. Decreased postinjection cold responsiveness, cold responsiveness did not differ reliably across postinjection times, and the interaction between drug treatment and injection time was not significant. Once daily dosing increased mechanical paw withdrawal thresholds relative to the vehicle-treated group across the observation interval.
分子量

231.25

Formula

C10H17NO5

性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (432.43 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3243 mL 21.6216 mL 43.2432 mL
5 mM 0.8649 mL 4.3243 mL 8.6486 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

(Rac)-ZLc-002 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3243 mL 21.6216 mL 43.2432 mL 108.1081 mL
5 mM 0.8649 mL 4.3243 mL 8.6486 mL 21.6216 mL
10 mM 0.4324 mL 2.1622 mL 4.3243 mL 10.8108 mL
15 mM 0.2883 mL 1.4414 mL 2.8829 mL 7.2072 mL
20 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4054 mL
25 mM 0.1730 mL 0.8649 mL 1.7297 mL 4.3243 mL
30 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6036 mL
40 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7027 mL
50 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
60 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
80 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3514 mL
100 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(Rac)-ZLc-002
目录号:
HY-124996
需求量: