2. Membrane Transporter/Ion Channel
  3. ATP Synthase
  4. ZW290

ZW290 是一种激活棕色脂肪组织 (BAT) 生热功能的化合物。ZW290 增加 BAT 中解偶联蛋白 1 (UCP1) 蛋白的表达并抑制 ATP 合成。

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ZW290 Chemical Structure

ZW290 Chemical Structure

CAS No. : 2411852-67-8

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ZW290 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT[1].

体外研究
(In Vitro)

棕色脂肪组织中的 ZW290 通过限制脂滴衍生脂肪酸的氧化并增加 UCP1 蛋白水平来诱导非颤抖产热[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZW290 相关抗体:
体内研究
(In Vivo)

ZW290（25-100 mg/kg；口服灌胃；每天一次；持续7天）显着降低BAT中脂滴的大小，增加棕色脂肪组织（BAT）和白色脂肪（WAT）中线粒体的含量和UCP1的表达组织。ZW290 可以延长小鼠的总生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Kunming (KM) mice (20 g) keeping under acute cold exposure (-20°C)[1]
Dosage: 25 mg/kg, 50 mg/kg, or 100 mg/kg
Administration: Oral gavage; once a day; for 7 days
Result: Notably decreased the size of lipid droplets in BAT and increased the content of mitochondria and the expression of UCP1 in BAT and WAT.
分子量

414.43

Formula

C20H18N2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZW290 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW2902411852-67-8ZW 290ZW-290ATP Synthasethermogenic functionATP synthesisUCP1 proteinoralInhibitorinhibitorinhibit

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