2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-23

α-Glucosidase-IN-23 是一种 α-Glucosidase 抑制剂，具有口服活性。α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖，IC50 值为 4.48 μM。α-Glucosidase-IN-23 可用于糖尿病的研究。

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α-Glucosidase-IN-23 Chemical Structure

α-Glucosidase-IN-23 Chemical Structure

CAS No. : 161187-57-1

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α-Glucosidase-IN-23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].

IC50 & Target

IC50: 4.48 μM (a-glucosidase)[1].
体外研究
(In Vitro)

α-Glucosidase-IN-23 (compound 8b) (1 μM) 具有显著的抗糖尿病作用[1]。
α-Glucosidase-IN-23 减少 β 细胞和肌肉细胞中的 ROS[1]。
α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖，IC50 值为 4.48 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-23 相关抗体:

Cell Proliferation Assay[1]

Cell Line: INS-1 Cells
Concentration: 1 μM
Incubation Time:
Result: Stimulated the growth of INS-1 cells in a dose-codependent approach.

Apoptosis Analysis[1]

Cell Line: INS-1 Cells
Concentration: 1 μM
Incubation Time:
Result: Restored the viability of INS-1 cells by about five times from apoptosis and eight times from necrosis.
体内研究
(In Vivo)

α-Glucosidase-IN-23（口服；0.2 mmol/kg/天）仅抑制小鼠体内的 α-葡萄糖苷酶[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 0.2 mmol/kg
Administration: Oral; 0.2 mmol/kg/day
Result:
Cmax (nmol/mL) Tmax (h) T1/2(h) AUC (ng/h/mL)
10.11 ± 1.17 0.8 ± 0.0 1.90 ± 1.04 36.7 ± 2.23
分子量

373.40

Formula

C20H23NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Glucosidase-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-23161187-57-1Glucosidaseα-Glucosidaseblood glucosediabetesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-148575
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