β-Lactoglobulin  (Synonyms: β-乳球蛋白)

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products^[1][2][3][4].

牛乳抗原 β-Lactoglobulin 经热处理后，由于结构变化和糖基化作用，可生成 RAGE、Gal-3、CD-36 和 SR-AI 的配体。糖基化的 β-Lactoglobulin 不易被消化，并能保持与 RAGE 和 Gal-3 的结合。消化后糖基化 β-Lactoglobulin 保留的免疫原性可能通过 RAGE 信号通路介导，并通过 Gal-3 促进内吞作用^[1]。
β-Lactoglobulin 具有抗氧化特性，因为它含有两个二硫键 (Cys-66 至 Cys-160，Cys-106 至 Cys-119) 和一个游离巯基 (Cys-121)^[2]。
β-Lactoglobulin 的结构独特，其刚性 β 桶状核心被一条长 α 螺旋和几条短 α 螺旋包围，核心内埋藏着两个二硫键和一个游离半胱氨酸巯基 (SH)。β-Lactoglobulin 有两种变体。变体 A (BLGA) 的氨基酸残基 Asp64 和 Val118 分别取代了变体 B (BLGB) 的 Gly64 和 Ala118。在生理条件下，这些变体以异源二聚体或同源二聚体的形式处于平衡状态^[3]。
β-Lactoglobulin 是淀粉样原纤维的组成单元，具有多种用途，包括稳定凝胶或乳液^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9045-23-2

固体

White to off-white

β-乳球蛋白

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Teodorowicz M, et al. Enhanced Uptake of Processed Bovine β-Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity. Mol Nutr Food Res. 2021;65(8):e2000834.  [Content Brief]

  [2]. Gołębiowski A, et al. Isolation and Self-Association Studies of Beta-Lactoglobulin. Int J Mol Sci. 2020;21(24):9711. Published 2020 Dec 19.  [Content Brief]

  [3]. Iwaoka M, et al. Oxidative folding pathways of bovine milk β-lactoglobulin with odd cysteine residues. FEBS Open Bio. 2019;9(8):1379-1391.  [Content Brief]

  [4]. Uttinger MJ, et al. Measurement of length distribution of beta-lactoglobulin fibrils by multiwavelength analytical ultracentrifugation. Eur Biophys J. 2020;49(8):745-760.  [Content Brief]