1. Immunology/Inflammation
  2. Interleukin Related
  3. 1,11b-Dihydro-11b-hydroxymedicarpin

1,11b-Dihydro-11b-hydroxymedicarpin  (Synonyms: 11b-Hydroxy-11b,1-dihydromedicarpin)

目录号: HY-N0976
产品使用指南

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) 是来自 Ononis viscosa 亚种 breviflora 的一种紫檀素,是 Medicarpin 衍生物。Medicarpin 是一种天然的紫檀素,通过激活 NotchWnt 经典信号通路来治愈皮质骨缺损。Medicarpin 通过阻止 TH17 细胞和促炎细胞因子的扩增来预防绝经后的关节炎。

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1,11b-Dihydro-11b-hydroxymedicarpin Chemical Structure

1,11b-Dihydro-11b-hydroxymedicarpin Chemical Structure

CAS No. : 210537-04-5

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生物活性

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

分子量

288.30

Formula

C16H16O5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

1,11b-Dihydro-11b-hydroxymedicarpin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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