2. Stem Cell/Wnt
  3. Wnt
  4. 15-Oxospiramilactone

15-Oxospiramilactone  (Synonyms: NC 043)

目录号: HY-111460 纯度: 98.96%
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15-Oxospiramilactone 是一种二萜衍生物。15-Oxospiramilactone 具有抑制 Wnt/β-catenin 信号传导和结肠癌细胞肿瘤发生的作用。

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15-Oxospiramilactone Chemical Structure

15-Oxospiramilactone Chemical Structure

CAS No. : 1053172-87-4

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1 mg ￥8500
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15-Oxospiramilactone 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit Wnt/β-catenin signaling and tumorigenesis of colon cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.22 μM
Compound: S-3
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 24684844]
HL-60 IC50
6.36 μM
Compound: S-3
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 24684844]
MCF7 IC50
3.25 μM
Compound: S-3
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24684844]
MEF IC50
1.736 μM
Compound: S-3
Induction of apoptosis in Bax(-/-)/Bak(-/-) MEF after 48 hrs
Induction of apoptosis in Bax(-/-)/Bak(-/-) MEF after 48 hrs
[PMID: 24684844]
SMMC-7721 IC50
3.96 μM
Compound: S-3
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 24684844]
SW480 IC50
1.7 μM
Compound: 62; NCO43
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33445154]
SW480 IC50
3.58 μM
Compound: S-3
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 24684844]
分子量

330.42

同用名

NC 043

Formula

C20H26O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

15-Oxospiramilactone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-Oxospiramilactone1053172-87-4NC 043NC043NC-043Wntsmall moleculeinhibitortumorigenesisInhibitorinhibit

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