2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. 6-Acetylnimbandiol

6-Acetylnimbandiol  (Synonyms: 6-O-Acetylnimbandiol)

目录号: HY-N10437
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摩尔计算器

6-Acetylnimbandiol (6-O-Acetylnimbandiol) 是一种无细胞毒性的 tyrosinase 抑制剂 (IC50=69.85 μM)，能有效抑制黑色素的生成和 MITF 的表达。6-Acetylnimbandiol 可用于黑色素瘤的研究。

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6-Acetylnimbandiol Chemical Structure

6-Acetylnimbandiol Chemical Structure

CAS No. : 1281766-66-2

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6-Acetylnimbandiol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research[1].

IC50 & Target[1]

Tyrosinas

69.85 μM (IC50)

体外研究
(In Vitro)

6-Acetylnimbandiol (10, 30, 100 µM; 48 h) shows antimelanogenic activity in B16 melanoma cells[1].
6-Acetylnimbandiol (50, 100 µM; 48 h) exerts melanogenesis inhibition by inhibiting expression of MITF, tyrosinase, TRP-1, and TRP-2 in B16 melanoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6-Acetylnimbandiol 相关抗体:

Cell Viability Assay[1]

Cell Line: B16 melanoma cells
Concentration: 10, 30, 100 µM
Incubation Time: 48 h
Result: Exhibited potent melanogenesis-inhibitory effect with 22.9% melanin content at 100 μM.

Western Blot Analysis[1]

Cell Line: B16 melanoma cells
Concentration: 50, 100 µM
Incubation Time: 48 h
Result: Inhibited tyrosinase with an IC50 value of 69.85 μM.
分子量

498.56

Formula

C28H34O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6-Acetylnimbandiol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

6-Acetylnimbandiol1281766-66-26-O-AcetylnimbandiolTyrosinaseB16 melanomamelanomaMITFTRP-1TRP-2Inhibitorinhibitorinhibit

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