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Chymase-IN-1 

目录号: HY-100269
产品使用指南

Chymase-IN-1 是一个有效的,有选择性的,口服有活性的人肥大细胞糜蛋白酶抑制剂,其 IC50 值为 29 nM。

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Chymase-IN-1 Chemical Structure

Chymase-IN-1 Chemical Structure

CAS No. : 862090-74-2

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

IC50 & Target

IC50: 29 nM (chymase)[1]

体外研究
(In Vitro)

Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

431.83

Formula

C20H15ClNO4PS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Chymase-IN-1
目录号:
HY-100269
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