Decoquinate  (Synonyms: 癸氧喹酯)

Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry^[1][2][3].

1. 体外抗疟实验：
Decoquinate (纳米制剂；48-72 h）在体外显著抑制恶性疟原虫肝期和血液期生长，肝期 IC₅₀ 为 2.18 ng/mL，血液期 IC₅₀ 为 0.05 ng/ml^[2]。
2. 衍生物活性实验：
Decoquinate 衍生物对 Chloroquine (HY-17589A) 敏感株 NF54 和耐药株 K1、W2 均有强效抑制，活性为 Decoquinate 的 5 倍，且对人成纤维细胞毒性低^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1. 球虫病防治实验：
Decoquinate (0.5-1 mg/kg；饲料给药；每日 1 次；至少 28 天) 在反刍动物 (犊牛、羔羊、山羊) 球虫病模型中有效抑制和预防球虫病，减少肠道损伤、卵囊排出，并改善宿主生长性能有效治疗和预防球虫病，减少肠道损伤及卵囊排出，并改善宿主生长性能^[1]。
2. 弓形虫预防实验：
Decoquinate (2 mg/kg；饲料给药；每日 1 次；持续 14 周) 在孕羊弓形虫感染模型中可预防弓形虫感染导致的流产和围产期损失，延缓发热反应并减少胎盘损伤^[1]。
3. 纳米制剂抗疟实验：
Decoquinate 纳米制剂 (1.25 mg/kg；口服；每日 1 次；3 天) 在小鼠疟原虫感染模型中显著抑制肝期疟原虫生长，效力是微粒制剂的 15 倍^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

417.54

C₂₄H₃₅NO₅

18507-89-6

固体

White to off-white

癸氧喹酯；敌可昆；癸喹酯

Room temperature in continental US; may vary elsewhere.

• [1]. Taylor MA, et, al. The history of decoquinate in the control of coccidial infections in ruminants. J Vet Pharmacol Ther. 2012 Oct;35(5):417-27.  [Content Brief]

  [2]. Wang H, et al. Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice. Nanomedicine. 2014 Jan;10(1):57-65.  [Content Brief]

  [3]. Beteck RM, et al. Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3006-3009.  [Content Brief]