2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Antifolate Endogenous Metabolite
  4. Folinic acid calcium salt pentahydrate

Folinic acid calcium salt pentahydrate  (Synonyms: 亚叶酸钙水合物; Leucovorin calcium salt pentahydrate)

目录号: HY-B0080 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为挽救剂服用，以降低 MTX 诱导的毒性。

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Folinic acid calcium salt pentahydrate Chemical Structure

Folinic acid calcium salt pentahydrate Chemical Structure

CAS No. : 6035-45-6

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规格 价格 是否有货 数量
100 mg ￥550
In-stock
500 mg ￥1800
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Folinic acid calcium salt pentahydrate:

Folinic acid calcium salt pentahydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Folinic acid calcium salt pentahydrate 相关抗体:
体内研究
(In Vivo)

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
分子量

601.58

Formula

C20H31CaN7O12
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

亚叶酸钙水合物
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
In Vitro: 

H2O 中的溶解度 : 10 mg/mL (16.62 mM; 超声助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6623 mL 8.3114 mL 16.6229 mL
5 mM 0.3325 mL 1.6623 mL 3.3246 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Folinic acid calcium salt pentahydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6623 mL 8.3114 mL 16.6229 mL 41.5572 mL
5 mM 0.3325 mL 1.6623 mL 3.3246 mL 8.3114 mL
10 mM 0.1662 mL 0.8311 mL 1.6623 mL 4.1557 mL
15 mM 0.1108 mL 0.5541 mL 1.1082 mL 2.7705 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Folinic acid calcium salt6035-45-6Leucovorin calcium salt亚叶酸钙水合物AntifolateEndogenous MetaboliteInhibitorinhibitorinhibit

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目录号：
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