1. Immunology/Inflammation
  2. IFNAR
  3. IFN alpha-IFNAR-IN-1

IFN alpha-IFNAR-IN-1 

目录号: HY-12836

IFN alpha-IFNAR-IN-1是IFN alpha和其受体IFNAR相互作用抑制剂,EC50值2-8uM。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 IFN alpha-IFNAR-IN-1 hydrochloride 通常具有更好的水溶性和稳定性。

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IFN alpha-IFNAR-IN-1 Chemical Structure

IFN alpha-IFNAR-IN-1 Chemical Structure

CAS No. : 844882-93-5

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IFN alpha-IFNAR-IN-1 的其他形式现货产品:

Other Forms of IFN alpha-IFNAR-IN-1:

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Top Publications Citing Use of Products

    IFN alpha-IFNAR-IN-1 purchased from MCE. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665.  [Abstract]

    PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three
    • 生物活性

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    • 参考文献


    IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IC50 value: Target: IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].





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    IFN alpha-IFNAR-IN-1 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.


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