2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. JTT 551

JTT 551 是一种选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，Ki 值为 0.22 μM，同时对 T 细胞蛋白酪氨酸磷酸酶 (TCPTP）也有作用，Ki 值为 9.3 μM，可用于二型糖尿病的研究。

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JTT 551 Chemical Structure

JTT 551 Chemical Structure

CAS No. : 776309-04-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥8260
In-stock
1 mg ￥2480
In-stock
5 mg ￥6200
In-stock
10 mg ￥9800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

JTT 551 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

IC50 & Target

IC50: 0.22 μM (PTP1B), 9.3 μM (TCPTP)[1]
体外研究
(In Vitro)

JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with Kis of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JTT 551 相关抗体:
体内研究
(In Vivo)

JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

605.85

Formula

C34H43N3O3S2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (165.06 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6506 mL 8.2529 mL 16.5057 mL
5 mM 0.3301 mL 1.6506 mL 3.3011 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
Db/db mice are used in the assay. JTT 551 at doses of 3 or 30 mg/kg or pioglitazone at 3 mg/kg is administered orally to 6-week-old male db/db mice (n = 5) once daily for 4 weeks. Body weight is measured twice weekly and blood samples are collected from the orbital venous plexus before dosing on Days 7, 14 and 28. Blood glucose, insulin, triglyceride (TG) and total cholesterol (TC) levels are determined at the respective blood-sampling time points, and the haemoglobin A1c (HbA1c) level is determined before dosing on Day 28. HbA1c level is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

JTT 551 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6506 mL 8.2529 mL 16.5057 mL 41.2643 mL
5 mM 0.3301 mL 1.6506 mL 3.3011 mL 8.2529 mL
10 mM 0.1651 mL 0.8253 mL 1.6506 mL 4.1264 mL
15 mM 0.1100 mL 0.5502 mL 1.1004 mL 2.7510 mL
20 mM 0.0825 mL 0.4126 mL 0.8253 mL 2.0632 mL
25 mM 0.0660 mL 0.3301 mL 0.6602 mL 1.6506 mL
30 mM 0.0550 mL 0.2751 mL 0.5502 mL 1.3755 mL
40 mM 0.0413 mL 0.2063 mL 0.4126 mL 1.0316 mL
50 mM 0.0330 mL 0.1651 mL 0.3301 mL 0.8253 mL
60 mM 0.0275 mL 0.1375 mL 0.2751 mL 0.6877 mL
80 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.5158 mL
100 mM 0.0165 mL 0.0825 mL 0.1651 mL 0.4126 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTT 551776309-04-7JTT551JTT-551PhosphataseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-19779
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