2. Anti-infection
  3. HCV
  4. Ledipasvir (diacetone)

Ledipasvir (diacetone)  (Synonyms: 雷迪帕韦双丙酮; GS-5885 diacetone)

目录号: HY-15602D
产品使用指南

摩尔计算器

Ledipasvir diacetone (GS-5885 diacetone) 是 Ledipasvir 的活性活性分子成分。Ledipasvir 是 hepatitis C virus NS5A 的有效抑制剂，能够抑制 GT1a 和 GT1b 复制子活性，EC50 值分别为 34 pM 和 4 pM。

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Ledipasvir (diacetone) Chemical Structure

Ledipasvir (diacetone) Chemical Structure

CAS No. : 1502655-48-2

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Ledipasvir (diacetone) 的其他形式现货产品:

Other Forms of Ledipasvir (diacetone):

Ledipasvir (diacetone) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 27 篇科研文献

WB

    Ledipasvir (diacetone) purchased from MCE. Usage Cited in: Antimicrob Agents Chemother. 2015 Jun;59(6):3482-92.  [Abstract]

    Assessment of HCV inhibition by DAAs from 3 classes using Western blot analysis. Jc1/Gluc2A virus-infected Huh-7.5.1 cells are treated with DMSO or the HCV inhibitors at concentrations of 100× EC50 (DCV, 3.2 nM; LDV, 3 μM; DNV, 0.32 μM; SOF, 20 μM). Cell lysates are harvested at 8 hpt (C and D) or at 24 hpt (A and B) and blotted for NS5A (A and C) or core (B and D). Data are normalized to GAPDH and quantified as relative fold change with respect to DMSO.

    • 生物活性

    • 纯度 & 产品资料

    生物活性

    Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

    体外研究
    (In Vitro)

    Ledipasvir diacetone is considered the active ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Ledipasvir (diacetone) 相关抗体:
    Clinical Trial
    分子量

    1005.16

    Formula

    C55H66F2N8O8
    CAS 号
    中文名称

    雷迪帕韦双丙酮
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    Ledipasvir (diacetone) 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ledipasvir (diacetone)1502655-48-2GS-5885 diacetone雷迪帕韦双丙酮HCVHepatitis C virusInhibitorinhibitorinhibit

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