2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Modecainide

Modecainide  (Synonyms: 莫地卡尼; BMY 40327; MJ 14030)

目录号: HY-101723 纯度: 99.36%
COA 产品使用指南

摩尔计算器

Modecainide 是Encainide 的一种主要代谢物，Encainid 是一种抗心律失常活性分子。

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Modecainide Chemical Structure

Modecainide Chemical Structure

CAS No. : 81329-71-7

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Customer Review

Modecainide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

体内研究
(In Vivo)

The effect of Encainide and its two major metabolites, O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway. MJ 9444 (0.05-0.4 mg/kg) speeds Purkinje conduction of early (less than 300 msec) without affecting or while slowing conduction of late (greater than 350 msec) extrasystoles. Higher doses (0.4-1.6 mg/kg) slows conduction at all intervals. The effective refractory period and the functional refractory period are decreased but in some cases returned to control values at the higher doses. Muscle conduction is slowed at doses of 0.4 mg/kg or more. MJ 14030 (0.05-3.2 mg/kg) has variable effects, behaving like MJ 9444 in three experiments but like the parent compound in two others[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

368.47

Formula

C22H28N2O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

莫地卡尼
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Methanol 中的溶解度 : ≥ 250 mg/mL (678.48 mM)

DMSO 中的溶解度 : 100 mg/mL (271.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7139 mL 13.5696 mL 27.1392 mL
5 mM 0.5428 mL 2.7139 mL 5.4279 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Modecainide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.7139 mL 13.5696 mL 27.1393 mL 67.8481 mL
5 mM 0.5428 mL 2.7139 mL 5.4279 mL 13.5696 mL
10 mM 0.2714 mL 1.3570 mL 2.7139 mL 6.7848 mL
15 mM 0.1809 mL 0.9046 mL 1.8093 mL 4.5232 mL
20 mM 0.1357 mL 0.6785 mL 1.3570 mL 3.3924 mL
25 mM 0.1086 mL 0.5428 mL 1.0856 mL 2.7139 mL
30 mM 0.0905 mL 0.4523 mL 0.9046 mL 2.2616 mL
40 mM 0.0678 mL 0.3392 mL 0.6785 mL 1.6962 mL
50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3570 mL
60 mM 0.0452 mL 0.2262 mL 0.4523 mL 1.1308 mL
80 mM 0.0339 mL 0.1696 mL 0.3392 mL 0.8481 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Modecainide81329-71-7BMY 40327 MJ 14030莫地卡尼BMY40327BMY-40327MJ14030MJ 14030MJ-14030Drug MetaboliteInhibitorinhibitorinhibit

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