1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Nav1.7-IN-3

Nav1.7-IN-3 

目录号: HY-101789 纯度: 98.43%
产品使用指南

Nav1.7-IN-3是选择性,有口服活性的电压门控钠离子通道 Nav1.7 抑制剂,IC50 为8 nM。CNS渗透能力有限。缓解疼痛。

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Nav1.7-IN-3 Chemical Structure

Nav1.7-IN-3 Chemical Structure

CAS No. : 1788872-06-9

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规格 价格 是否有货 数量
5 mg ¥4000
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10 mg ¥6800
In-stock
25 mg ¥13500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration[1].

IC50 & Target

IC50: 8 nM (Nav1.7)[1]

体内研究
(In Vivo)

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (n=8/group, 25-30g)
Dosage: 1, 3, and 10 mg/kg
Administration: Oral (0-35 mintues)
Result: Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase[1]
分子量

430.95

Formula

C17H20ClFN4O2S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

参考文献
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  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Nav1.7-IN-3
目录号:
HY-101789
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