Neurokinin A(4-10)  (Synonyms: 神经激肽 A (4-10))

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

NK₂ receptor^[1]

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK₂ receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK₂ receptor in human colon circular muscle. A high density of NK₂ receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

766.91

C₃₄H₅₄N₈O₁₀S

97559-35-8

Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

DSFVGLM-NH2

神经激肽 A (4-10)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.  [Content Brief]