1. PROTAC
  2. Ligands for Target Protein for PROTAC
  3. SirReal1-O-propargyl

SirReal1-O-propargyl  (Synonyms: PROTAC Sirt2-binding moiety 1)

目录号: HY-107453
产品使用指南

SirReal1-O-propargyl 是Sirtuin 2 (Sirt2) 选择性的、强效抑制剂,IC50 值为 2.4 μM。SirReal1-O-propargyl 是一种基于 SirReal1的配体,可通过 linker 与 cereblon 配体结合形成 PROTAC分子,从而降解Sirt2。SirReal1-O-propargyl 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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SirReal1-O-propargyl Chemical Structure

SirReal1-O-propargyl Chemical Structure

CAS No. : 1862237-99-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1]. SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 2.4 μM (Sirt2)[1].

分子量

424.54

Formula

C21H20N4O2S2

CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

SirReal1-O-propargyl 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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