Risedronic acid (Synonyms: 利塞膦酸; Risedronate)

目录号: HY-B0148 纯度: ≥98.0%: Data Sheet SDS COA 产品使用指南
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Risedronic acid (Risedronate) 是一种双膦酸盐和有效的抗骨吸收剂。Risedronic acid 诱导凋亡 (Apoptosis)。Risedronic acid 可抑制 farnesyl pyrophosphate 基团向寄生虫 (parasite) 蛋白的转移。Risedronic acid 可抑制破骨细胞介导的骨吸收并改变骨代谢。Risedronic acid 可抑制血液阶段恶性疟原虫 (IC₅₀ 为 20.3 μM)。

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Risedronic acid Chemical Structure

CAS No. : 105462-24-6

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10 mg	￥198	In-stock
25 mg	￥303	In-stock
50 mg	￥429	In-stock
100 mg	￥600	In-stock
500 mg	￥1500	In-stock
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Customer Review

Other Forms of Risedronic acid:

MCE 顾客使用本产品发表的 2 篇科研文献

Risedronic acid 相关产品

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
纯度 & 产品资料
参考文献

生物活性

Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM)^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	16 μM Compound: Risedronate	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	[PMID: 20457823]
JJN-3	EC₅₀	10 μM Compound: 2	Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay Antiproliferative activity against human JJN-3 after 72 hrs by MTT assay	[PMID: 22390415]
MCF7	IC₅₀	248 μM Compound: Risedronate	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 24 to 48 hrs by SRB assay	[PMID: 33132173]
MCF7	IC₅₀	35.7 μM Compound: 1	Antiproliferative activity against human MCF7 cell line by MTT assay Antiproliferative activity against human MCF7 cell line by MTT assay	[PMID: 16970405]
NCI-H460	IC₅₀	43.7 μM Compound: 1	Antiproliferative activity against human NCI-H460 cell line by MTT assay Antiproliferative activity against human NCI-H460 cell line by MTT assay	[PMID: 16970405]
RPMI-8226	EC₅₀	13 μM Compound: 2a	Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay	[PMID: 23998921]
SF-268	IC₅₀	23.3 μM Compound: 1	Antiproliferative activity against human SF-268 cell line by MTT assay Antiproliferative activity against human SF-268 cell line by MTT assay	[PMID: 16970405]
T-cell	IC₅₀	6.2 μM Compound: 8	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL	[PMID: 14711309]
T-cell	IC₅₀	6.9 μM Compound: 8	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release	[PMID: 14711309]
Vero	ED₅₀	55 μM Compound: Risedronate	Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay	[PMID: 23318904]
Vero	ED₅₀	55 μM Compound: 5	Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay	[PMID: 24300918]

体外研究
(In Vitro)

Risedronic acid (0-10 μM；14 天) 在人骨髓间充质干细胞 (hMSC12) 和大鼠胸腺来源的间充质干细胞 (ST1BIIb) 中抑制了矿化结节的形成^[1]。
Risedronic acid (0-10 μM；3 天) 在人骨髓间充质干细胞 (hMSC12) 中抑制了成骨细胞标记基因骨钙素 (OC) 的 mRNA 表达^[1]。
Risedronic acid (100-1000 μM；48 h) 在人骨髓间充质干细胞 (hMSC12) 中诱导了染色质浓缩，激活了半胱天冬酶-3^[1]。
Risedronic acid (Risedronate) (15 μM；36 h) 在恶性疟原虫中抑制了类异戊二烯生物合成，表现为法尼醇 (FOH) 和香叶基香叶醇 (GGOH) 等相关条带强度降低^[3]。
Risedronic acid (15 μM；36 h) 在恶性疟原虫中干扰了蛋白质异戊烯化，使法尼基化蛋白条带强度降低，香叶基香叶基化蛋白条带强度增加^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis¹

Cell Line:	Human mesenchymal stem cells (hMSC12)
Concentration:	100 μM, 300 μM, 500 μM, 1000 μM
Incubation Time:	48 h
Result:	Induced chromatin condensation and activated caspase-3.

体内研究
(In Vivo)

Risedronic acid (Risedronate) (30 μg/kg；皮下注射；隔天 1 次；3 周) 在全身照射 2 Gy X 射线的雌性 C57BL/6 小鼠中，预防了辐射诱导的骨质疏松，阻止了小梁骨丢失和微结构损伤，抑制了破骨细胞数量和血清 TRAP5b 的增加^[2]。
Risedronic acid (10-25 mg/kg；腹腔注射；每天 1 次；7 天) 在感染伯氏疟原虫（Plasmodium berghei）ANKA 株的 BALB/c 小鼠中，抑制了寄生虫血症，但未延长小鼠存活时间^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body²
Dosage:	30 μg/kg
Administration:	Subcutaneous injection, once every other day, for 3 weeks
Result:	Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.

Animal Model:	Male BALB/c mice (3-4 weeks old) infected with Plasmodium berghei strain ANKA by intraperitoneal injection of 1×10⁶ blood-stage parasites³
Dosage:	10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:	Intraperitoneal injection, once a day, for 7 days
Result:	Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.

Clinical Trial

分子量

283.11

Formula

C₇H₁₁NO₇P₂

CAS 号

105462-24-6

性状

固体

颜色

White to off-white

中文名称

利塞膦酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

溶解性数据

细胞实验：

0.1 M NaOH 中的溶解度 : 11 mg/mL (38.85 mM; ultrasonic and adjust pH to 7 with NaOH)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5322 mL	17.6610 mL	35.3220 mL
5 mM	0.7064 mL	3.5322 mL	7.0644 mL
10 mM	0.3532 mL	1.7661 mL	3.5322 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (639 KB) SDS (393 KB)

COA (297 KB) HNMR (253 KB) CNMR (309 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Fujita H, et al. Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells. Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):78-84. [Content Brief]

[2]. Willey JS, et al. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone. 2010 Jan;46(1):101-11. [Content Brief]

[3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31. [Content Brief]

Risedronic acid 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

0.1 M NaOH	1 mM	3.5322 mL	17.6610 mL	35.3220 mL	88.3049 mL
	5 mM	0.7064 mL	3.5322 mL	7.0644 mL	17.6610 mL
	10 mM	0.3532 mL	1.7661 mL	3.5322 mL	8.8305 mL
	15 mM	0.2355 mL	1.1774 mL	2.3548 mL	5.8870 mL
	20 mM	0.1766 mL	0.8830 mL	1.7661 mL	4.4152 mL
	25 mM	0.1413 mL	0.7064 mL	1.4129 mL	3.5322 mL
	30 mM	0.1177 mL	0.5887 mL	1.1774 mL	2.9435 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Risedronic acid105462-24-6Risedronate利塞膦酸ParasiteApoptosisparasitehMSC12Plasmodium bergheiInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Risedronic acid (Synonyms: 利塞膦酸; Risedronate)

Customer Review

Other Forms of Risedronic acid:

MCE 顾客使用本产品发表的 2 篇科研文献