2. Metabolic Enzyme/Protease
  3. Neprilysin
  4. SCH 42495

SCH 42495 是一种具有口服活性的中性金属内肽酶 (NEP) 抑制剂，具有抗高血压活性。SCH 42495 是 SCH 42354 的口服活性前体。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SCH 42495 Chemical Structure

SCH 42495 Chemical Structure

CAS No. : 136511-43-8

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Other Forms of SCH 42495:

SCH 42495 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[1].

IC50 & Target

NEP[1]
体外研究
(In Vitro)

SCH 42354 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC50 of 8.3 and 10.0 nM, respectively) in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SCH 42495 相关抗体:
体内研究
(In Vivo)

SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days[2].
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2].
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypoxic rats[2]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily for 10 days
Result: Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia.
分子量

411.58

Formula

C20H29NO4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SCH 42495 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 42495136511-43-8SCH42495SCH-42495NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10chronichypoxianeutralendopeptidasepulmonaryhypertensionvascularremodellingInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-101682
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