1. Metabolic Enzyme/Protease
  2. Neprilysin
  3. SCH 42495 racemate

SCH 42495 racemate 是 Sch-42495 的外消旋体。SCH 42495 是一种具有口服活性的中性金属内肽酶 (NEP) 抑制剂,具有抗高血压活性。SCH 42495 是 SCH 42354 的口服活性前体。

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SCH 42495 racemate Chemical Structure

SCH 42495 racemate Chemical Structure

CAS No. : 145841-10-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[1].

IC50 & Target

NEP[1]

体外研究
(In Vitro)

SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC50 of 8.3 and 10.0 nM, respectively) in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days[2].
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2].
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypoxic rats[2]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily for 10 days
Result: Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia.
分子量

411.58

Formula

C20H29NO4S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

SCH 42495 racemate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SCH 42495 racemate
目录号:
HY-101682A
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