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  3. (R)-SCH 42495

(R)-SCH 42495 是 SCH 42495 的低活性异构体。SCH 42495 是一种具有口服活性的中性金属内肽酶 (NEP) 抑制剂,具有抗高血压活性。SCH 42495 是 SCH 42354 的口服活性前体。

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(R)-SCH 42495 Chemical Structure

(R)-SCH 42495 Chemical Structure

CAS No. : 156792-25-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[2].

体外研究
(In Vitro)

NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

411.58

Formula

C20H29NO4S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

(R)-SCH 42495 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(R)-SCH 42495
目录号:
HY-101682B
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