2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Seco Rapamycin sodium salt

Seco Rapamycin sodium salt  (Synonyms: Seco雷帕霉素钠盐; Secorapamycin A monosodium)

目录号: HY-19555A 纯度: 85.18%
COA 产品使用指南

摩尔计算器

Seco Rapamycin sodium salt 是 Rapamycin 的开环代谢物。Seco-Rapamycin 几乎不影响 mTOR 功能。

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Seco Rapamycin sodium salt Chemical Structure

Seco Rapamycin sodium salt Chemical Structure

CAS No. : 148554-65-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5664
In-stock
1 mg ￥1590
In-stock
5 mg ￥3500
In-stock
10 mg ￥5500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Seco Rapamycin sodium salt:

Seco Rapamycin sodium salt 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Seco Rapamycin sodium salt is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function.

体外研究
(In Vitro)

Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20 μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100 μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20 μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Seco Rapamycin sodium salt 相关抗体:
分子量

936.15

Formula

C51H78NNaO13
CAS 号
性状

固体

颜色

White to yellow

中文名称

Seco雷帕霉素钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 46 mg/mL (49.14 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0682 mL 5.3410 mL 10.6820 mL
5 mM 0.2136 mL 1.0682 mL 2.1364 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

To determine whether the Sirolimus metabolite M2 is formed from the degradation product Seco Rapamycin, duplicate Caco-2 cell cultures are dosed apically or basolaterally with 20 μM Seco Rapamycin and incubated for 4 h. To determine whether Seco Rapamycin is a substrate for P-gp, duplicate cultures are incubated with 0.5 μM LY335979 in the same manner for Sirolimus. For comparison, a parallel set of cultures is incubated similarly with 20 μM Sirolimus, but dosed apically only. M2 formation is also examined in human jejunal mucosal and liver homogenates and Caco-2 homogenates by incubating each preparation, in duplicate, with 20 μM Seco Rapamycin in the same manner for Sirolimus. For comparison, a parallel set of incubations containing 20 μM Sirolimus is also performed. To determine whether a high dose of Ketoconazole (100 μM) inhibits the formation of M2, parallel experiments with Caco-2 cells and the various homogenates are performed in a similar manner, only Ketoconazole (dissolved as a 100-fold concentration solution in ethanol) is included in the incubation medium/mixtures[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Seco Rapamycin sodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0682 mL 5.3410 mL 10.6820 mL 26.7051 mL
5 mM 0.2136 mL 1.0682 mL 2.1364 mL 5.3410 mL
10 mM 0.1068 mL 0.5341 mL 1.0682 mL 2.6705 mL
15 mM 0.0712 mL 0.3561 mL 0.7121 mL 1.7803 mL
20 mM 0.0534 mL 0.2671 mL 0.5341 mL 1.3353 mL
25 mM 0.0427 mL 0.2136 mL 0.4273 mL 1.0682 mL
30 mM 0.0356 mL 0.1780 mL 0.3561 mL 0.8902 mL
40 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.6676 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seco Rapamycin148554-65-8Secorapamycin A monosodiumSeco雷帕霉素钠盐Drug MetaboliteInhibitorinhibitorinhibit

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