1. Signaling Pathways
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  3. Arp2/3 Complex

Arp2/3 Complex

The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.

The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.

Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements.

Arp2/3 Complex 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-16928
    Cytochalasin B >99.0%
    Cytochalasin B 是一种能透过细胞的真菌毒素,能够与肌动蛋白丝的有刺端结合,扰乱肌动蛋白聚合物的形成,对 F-actin 的 Kd 值为 1.4-2.2 nM。
  • HY-15892
    CK-636 Inhibitor 98.10%
    CK-636是具有细胞渗透性的Arp2/3 复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的 IC50 值分别为4 μM,24 μM和32 μM。
  • HY-16926
    CK-666 Inhibitor 99.63%
    CK-666 是一种细胞渗透性的与肌动蛋白相关的蛋白质 Arp2/3 复合物的抑制剂,它结合 Arp2/3 复合物,稳定复合物的非活性状态,阻止 Arp2 和 Arp3 亚单位移动进入激活的丝状构象。
  • HY-N6682
    Cytochalasin D Inhibitor >99.0%
    Cytochalasin D (Zygosporin A; NSC 209835) 是一种有效、细胞渗透性的肌动蛋白聚合抑制剂,由真菌产生,通过绑定 G-actin 抑制 G-actin–cofilin 的相互作用。Cytochalasin D (Zygosporin A; NSC 209835) 还能抑制 cofilin 与 F-actin 的结合,降低了活细胞中肌动蛋白聚合和解聚的速率。
  • HY-16927
    CK-869 Inhibitor 99.76%
    CK-869 是肌动蛋白相关蛋白 2/3 复合体 (ARP2/3) 的抑制剂,其 IC50 值为 7 μM。
  • HY-16929
    Latrunculin A Inhibitor
    Latrunculin A (LAT-A) 是从红海海绵 Latrunculia magnifica 中得到的一种毒素,能够与肌动蛋白 (actin) 单体结合,抑制肌动蛋白聚集,对 ATP-actin,ADP-Pi-actin,ADP-actin 和 G-actin 的 Kd 值分别为 0.1,0.4,4.7 μM 和 0.19 μM。
  • HY-N6701
    Dihydrocytochalasin B Inhibitor
    Dihydrocytochalasin B 二氢细胞松弛素 B 是一种细胞分裂抑制剂 (Cytokinesis),可改变细胞的形态,与细胞松弛素 B 相似。Dihydrocytochalasin B 不抑制葡萄糖转运。Dihydrocytochalasin B 二氢细胞松弛素 B 破坏肌动蛋白结构并抑制生长因子刺激 DNA 合成的能力,可逆地阻断 DNA 合成的起始。Dihydrocytochalasin B 二氢细胞松弛素 B 抑制活性钙转运。
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