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  3. Benproperine phosphate

Benproperine phosphate 

目录号: HY-114657A
产品使用指南

Benproperine phosphate 是一种具有口服活性的,有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳,并可以抑制癌细胞迁移和肿瘤转移。

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Benproperine phosphate Chemical Structure

Benproperine phosphate Chemical Structure

CAS No. : 19428-14-9

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Description

Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1].

In Vitro

Benproperine phosphate (20-120 μM; for 24 hours) inhibits cell viability in a dose-dependent manner[1].
Benproperine phosphate (10 μM; for 24 hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2 μM. Benproperine phosphate (10 μM; for 24 hours) does not affect cortactin-rich lamellipodium in MCF-10A cells[1].

Cell Viability Assay[1]

Cell Line: DLD-1, AsPC-1, CFPAC-1, A375P, A375P, MDA-MB-231, DU145, DU145 cancer cells
Concentration: 20, 40, 60, 80, 100, 120 μM
Incubation Time: For 24 hours
Result: Inhibited cell viability in a dose-dependent manner.
In Vivo

Benproperine phosphate (50, 100 mg/kg; oral gavage; 5 days per week for 4 weeks) inhibits primary pancreatic tumor growth[1].
Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1].

Animal Model: Female BALB/c nude mice of 6-week-old with AsPC-1 cells[1]
Dosage: 50, 100 mg/kg
Administration: Oral gavage; 5 days per week for 4 weeks
Result: Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.
Molecular Weight

407.44

Formula

C₂₁H₃₀NO₅P

CAS No.

19428-14-9

中文名称

苯丙哌林;科福乐

SMILES

CC(N1CCCCC1)COC2=CC=CC=C2CC3=CC=CC=C3.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
C1   V1   C2   V2

Keywords:

BenproperineArp2/3 ComplexActin-related protein 2/3 complexorallyactin-relatedprotein2/3complexsubunitARPC2polymerizationratecoughmigrationmetastasisDLD-1AsPC-1CFPAC-1A375PMDA-MB-231DU145Inhibitorinhibitorinhibit

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Benproperine phosphate
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HY-114657A
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