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  3. Jasplakinolide

Jasplakinolide 

目录号: HY-P0027
产品使用指南

Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂,可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白,Kd 值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽,具有抗真菌和抗肿瘤活性。

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Jasplakinolide Chemical Structure

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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100 μg ¥8800 Ask For Quote & Lead Time

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Description

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

In Vitro

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

Molecular Weight

709.67

Formula

C₃₆H₄₅BrN₄O₆

CAS No.

102396-24-7

SMILES

BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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Keywords:

JasplakinolideArp2/3 ComplexFungalActin-related protein 2/3 complexactinpolymerizationinducerstabilizesF-actinphalloidincyclicpeptidemarinespongefungicidalanti-cancerInhibitorinhibitorinhibit

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产品名称:
Jasplakinolide
目录号:
HY-P0027
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