1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrase is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2+H2O<-->HCO3-+H+. The enzyme is the target for drugs, such as Acetazolamide, Methazolamide, and Dichlorphenamide, for the treatment of glaucoma. There are three evolutionarily unrelated CA families, designated alpha, beta, and gamma. All known CAs from the animal kingdom are of the alpha type. There are seven mammalian CA isozymes with different tissue distributions and intracellular locations, CA I-VII.

Carbonic anhydrase is one of the core enzyme in organism, which involves in osmoregulation, ionic regulation, acid-base regulation and other physiological and biochemical process.

Carbonic Anhydrase 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-B0782
    Acetazolamide Inhibitor 99.87%
    Acetazolamide 是一种碳酸酐酶 (carbonic anhydraseCA) IX 抑制剂,抑制 hCA IXIC50 为 30 nM。利尿剂。
  • HY-13650
    Indisulam Inhibitor 99.35%
    Indisulam (E 7070) 是一种碳酸酐酶抑制剂,具有抗癌活性。Indisulam (E 7070) 是细胞周期 G1 期的靶向化合物。Indisulam (E 7070) 通过抑制 CDK2周期蛋白 E 的激活,引起 G1/S 转化被阻滞。Indisulam (E 7070) 通过募集 DCAF15 诱导 RBM39 降解来靶向剪接。
  • HY-B0553
    Methazolamide Inhibitor 99.80%
  • HY-B0122
    Topiramate Inhibitor >98.0%
    Topiramate (McN 4853) 是一种广谱抗癫痫药。Topiramate 也是一种 GluR5 受体拮抗剂,可通过增强 GABAergic 活性,抑制 kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。
  • HY-B1480
    Ethoxzolamide Inhibitor 98.78%
    Ethoxzolamide 是 carbonic anhydrase 的抑制剂,其 Ki 值为 1 nM。
  • HY-110234
    Topiramate D12 Inhibitor
    Topiramate D12 (McN 4853 D12) 是Topiramate 的氘代物。Topiramate 是一种广谱抗癫痫药。Topiramate 也是一种 GluR5 受体拮抗剂,可通过增强 GABAergic 活性,抑制 kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。
  • HY-B1424
    Benzthiazide Inhibitor >99.0%
    Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂,对 CA9,CA2 和 CA1 的 Ki 值分别为 8.0,8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。
  • HY-B0397
    Dichlorphenamide Inhibitor >98.0%
  • HY-13513
    U-104 Inhibitor 99.55%
    U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂,Ki值分别为45.1nM和4.5nM。
  • HY-B0588
    Brinzolamide Inhibitor 99.78%
    Brinzolamide(AL 4862)是碳酸酐酶(carbonic anhydrase)II抑制剂,IC50为3.19 nM。
  • HY-B0109A
    Dorzolamide hydrochloride Inhibitor 99.47%
    Dorzolamide (L671152; MK507) 盐酸盐是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0782S
    Acetazolamide D3 Inhibitor
    Acetazolamide D3是Acetazolamide氘代化合物标准品。
  • HY-108316
    Sultiame Inhibitor 99.11%
    Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。
  • HY-N0085
    Dimethylfraxetin Inhibitor 99.97%
    Dimethylfraxetin 是一种 Carbonic anhydrase 抑制剂,其 Ki 值为 0.0097 μM。
  • HY-B0109
    Dorzolamide Inhibitor
    Dorzolamide(L671152; MK507)是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0483
    Tioxolone Inhibitor >98.0%
    Tioxolone是金属酶碳酸酐酶(metalloenzyme carbonic anhydrase)I抑制剂,有抗痤疮活性。
  • HY-B2147
    2-Aminobenzenesulfonamide Inhibitor 99.88%
    2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。
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