1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. CAIX Inhibitor S4

CAIX Inhibitor S4 

目录号: HY-110243 纯度: 98.90%
COA 产品使用指南

CAIX Inhibitor S4 是一种有效和选择性的碳酸酐酶 IX/XII (CA IX/XII) 的抑制剂,Ki 值分别为 7 nM 和 2 nM。CAIX Inhibitor S4 还抑制 CA IICA I (Ki=546 nM, 5600 nM)。CAIX Inhibitor S4 可以抑制原位 MDA-MB-231 小鼠模型中肺转移的数量,而不影响原发肿瘤的生长。

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CAIX Inhibitor S4 Chemical Structure

CAIX Inhibitor S4 Chemical Structure

CAS No. : 1330061-67-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥770
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1 mg ¥280
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5 mg ¥700
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10 mg ¥1200
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25 mg ¥2500
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50 mg ¥4500
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100 mg ¥7500
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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Carbonic Anhydrase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

IC50 & Target

Ki: 2 nM (CA XII), 7 nM (CA IX), 546 nM (CA II), 5600 nM (CA I)[1]

体外研究
(In Vitro)

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116 and HT29 cells
Concentration: 1, 10, 100 μM
Incubation Time: 24 hours
Result: Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC50s of 481 μM, >1000 μM, and 20 μM, respectively.
体内研究
(In Vivo)

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1]
Dosage: 10 mg/kg
Administration: I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result: Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.
分子量

335.38

Formula

C15H17N3O4S

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 250 mg/mL (745.42 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9817 mL 14.9085 mL 29.8169 mL
5 mM 0.5963 mL 2.9817 mL 5.9634 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CAIX Inhibitor S4 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9817 mL 14.9085 mL 29.8169 mL 74.5423 mL
5 mM 0.5963 mL 2.9817 mL 5.9634 mL 14.9085 mL
10 mM 0.2982 mL 1.4908 mL 2.9817 mL 7.4542 mL
15 mM 0.1988 mL 0.9939 mL 1.9878 mL 4.9695 mL
20 mM 0.1491 mL 0.7454 mL 1.4908 mL 3.7271 mL
25 mM 0.1193 mL 0.5963 mL 1.1927 mL 2.9817 mL
30 mM 0.0994 mL 0.4969 mL 0.9939 mL 2.4847 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8636 mL
50 mM 0.0596 mL 0.2982 mL 0.5963 mL 1.4908 mL
60 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2424 mL
80 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9318 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CAIX Inhibitor S4
目录号:
HY-110243
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